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KMID : 0624620170500030109
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BMB Reports
2017 Volume.50 No. 3 p.109 ~ p.110
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Calcium-activated chloride channels: a new target to control the spiking pattern of neurons
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Ha Go-Eun
Cheong Eun-Ji
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Abstract
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The nature of encoded information in neural circuits is determined by neuronal firing patterns and frequencies. This paper discusses the molecular identity and cellular mechanisms of spike-frequency adaptation in the central nervous system (CNS). Spike-frequency adaptation in thalamocortical (TC) and CA1 hippocampal neurons is mediated by the Ca2+-activated Cl? channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in these neurons results in increased number of spikes, in conjunction with significantly reduced spike-frequency adaptation. No study has so far demonstrated that CACCs mediate afterhyperpolarization currents, which result in the modulation of neuronal spike patterns in the CNS. Our study therefore proposes a novel role for ANO2 in spike-frequency adaptation and transmission of information in the brain.
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KEYWORD
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Afterhyperpolarization, Anoctamin-2, Calcium-activated chloride channel, Spike-frequency adaptation, Thalamocortical neuron
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